FIRST-TIER NEXT-GENERATION SEQUENCING FOR NEWBORN SCREENING: AN IMPORTANT ROLE FOR BIOCHEMICAL SECOND-TIER TESTING

First-tier next-generation sequencing for newborn screening: An important role for biochemical second-tier testing

There is discussion of expanding newborn screening (NBS) through the use of genomic sequence data; yet, challenges remain in the interpretation of DNA variants.Population-level DNA variant databases are available, and it is possible to estimate the number of newborns who would be flagged as having a risk for a genetic disease (including rare varian

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Two inequalities about the pedal triangle

Abstract Two conjectures about the pedal triangle are proved.For the first conjecture, the product of the distances from an interior point to the vertices is mainly considered Slip Covers and a lower bound is obtained by the geometric method.To prove the other one, an analytic expression of the distance between the circumcenter and an interior poin

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